WebThe bifunctional 6-phosphofructo-2-kinase (EC 2.7.1.105)/fructose-2,6-bisphosphatase (EC 3.1.3.46) ... Blocking this enzyme in prostate cancer cells grown in the lab stalled growth and triggered a catastrophic build-up of free-radicals, suggesting that it could be a suitable drug target. Importantly, this route to energy production is common to ... WebDec 10, 2024 · CD44 represents a common biomarker of cancer stem cells, and promotes epithelial-mesenchymal transition. CD44 is involved in the regulation of diverse vital signaling pathways that modulate cancer proliferation, invasion, metastasis and therapy-resistance, and it is also modulated by a variety of molecules in cancer cells.
代表性论著 - 吕志民实验室 - 浙江大学转化医学研究院
WebJan 2, 2024 · Cancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumor microenvironment. High plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancer cells. To respond to nutrient stress and to meet the … WebThe proliferation of cancer cells needs a high rate of energy and metabolic substrates for biosynthesis of biomolecules. These requirements are met by the metabolic … theft disable menu gateway monitor
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2
WebRenewed interest in this field in cancer research more generally has led to the development of new drugs and re-purposing of existing drugs that target cellular metabolism, which, when combined with standard therapies can offer a selective therapeutic gain ... and direct inhibition of fructose-1,6-bisphosphatase . WebMay 21, 2024 · The PFKFB3 protein is a homodimer, each monomer of which consists of 2 different functional domains: the N-terminal, which contains the kinase domain that is responsible for the synthesis of fructose-2,6-biphosphate (F2,6P2); and the C-terminal domain, which contains the bisphosphatase active site that is responsible for the … WebFructose-1,6-Bisphosphatase (FBPase) Deficiency FBPase is a key gluconeogenic enzyme, catalyzing the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate. Two different paralogs exist in humans; FBP1 is found in the liver, and FBP2 is found in muscle. theft disciplinary hearing