WebCTCFL is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes. CTCFL is normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. WebThe CCCTC-binding factor (CTCF), which anchors DNA loops that organize the genome into structural domains, has a central role in gene control by facilitating or constraining interactions between genes and their regulatory elements 1,2.In cancer cells, the disruption of CTCF binding at specific loci by somatic mutation 3,4 or DNA hypermethylation 5 …
Early vertebrate origin of CTCFL, a CTCF paralog, revealed by …
WebNov 30, 2010 · Transcriptional repressor CTCFL. Gene. CTCFL. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 663. Protein existence. Evidence at protein level ... (expression overlapping with the genome-wide erasure of methylation) to become silenced on activation of CTCF in post-meiotic … WebAug 24, 2024 · Because CTCF and CTCFL do not appear to recruit each other , CTCF may maintain chromatin accessibility at tandem CTCF-binding sites, thereby recruiting CTCFL to nearby genes and initiating transcription. In contrast, most gene promoters were highly depleted of nucleosomes, resulting from combinatorial TF binding. In these sites, loss of … ionaf cnbc
The cancer-associated CTCFL/BORIS protein targets multiple
WebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ... WebAug 7, 2024 · By contrast, the germ-cell-specific paralogue of CTCF, BORIS (brother of the regulator of imprinted sites, also known as CTCFL)6, is overexpressed in several cancers7–9, but its contributions to ... WebAug 31, 2016 · The germline-specific transcription factor BORIS/CTCFL, a paralog of chromatin architecture protein CTCF, is often erroneously activated in cancers and … ionad cultúrtha