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WebMay 27, 2024 · Answer From Sheldon G. Sheps, M.D. Yes, some diuretics — also called water pills — decrease potassium in the blood. Diuretics are commonly used to treat high blood pressure (hypertension). They lower blood pressure by helping the body eliminate sodium and water through the urine. WebSep 19, 2024 · Hydrochlorothiazide reduces the elimination of lithium ( Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity. Nonsteroidal anti-inflammatory drugs ( NSAIDs ), for example, ibuprofen ( Motrin ), may reduce the blood pressure lowering effects of hydrochlorothiazide. WebThiazide diuretics, such as chlorothiazide (Diuril), chlorthalidone (Hygroton), and hydrochlorothiazide (Esidrix, HydroDiuril, Microzide) tend to deplete potassium levels. So … grand southern trunk road